SMRT Sequencing

Unlock the potential of long-read sequencing with our Single Molecule, Real-Time (SMRT) sequencing services. We offer more than just raw data; our customized analysis taps into the advantages of long-read sequencing, providing a holistic view of the genome and its complexities. Our services encompass detection of structural variations, complex genomic regions analysis, and comprehensive epigenetic methylation landscape mapping. Harness the power of SMRT sequencing with us and explore deeper genomic insights to propel your groundbreaking research to new frontiers.


Additional benefits:


3-year warranty and safe storage of data with unlimited access: The generation of sequencing data can lead to large and complex data sets, demanding significant storage space that may not be readily available or cost-effective for individual researchers or smaller institutions. By storing raw and analyzed data on our secure servers, we relieve you of the burden of data management. Additionally, the three-year unlimited access allows you to revisit and analyze the data for new insights as your research evolves, which is particularly valuable for long-term projects and follow-up studies.


24-hour response time: By providing timely responses, we ensure that these crucial insights aren't lost or delayed, allowing for the necessary adjustments to the analysis or experiment design to be made swiftly. This quick feedback loop aids you in keeping your project on track, enhances the iterative process of scientific inquiry, and ultimately contributes to more robust and insightful outcomes. With us, your questions are promptly addressed, keeping your research moving forward without delay.


Hard to process sample preparation: Nucleic acid isolation can be a challenging process, especially from difficult-to-process samples such as formalin-fixed, paraffin-embedded (FFPE) sections. For many researchers, especially those without access to specialized lab equipment or expertise, this can be a significant hurdle. However, with our service, we eliminate this concern. We handle the complex process of nucleic acid isolation from any sample you provide, ensuring that even the most challenging materials are effectively processed.


Ready to use full materials and methods and publication data: Providing a ready-to-use, comprehensive materials and methods and descriptions is a key component of our service. Drafting a materials and methods section can be time-consuming and complex, potentially requiring several hours to days of a researcher's time depending on the complexity of the procedures used. By supplying a detailed, publication-ready description, we free up significant time for our customers.

Information requested when ordering a product:


Examples Of What You Can Do

SMRT sequencing is a potent tool for genome-wide epigenetic studies, as it facilitates the identification of DNA modifications with single-molecule precision. Unlike alternative sequencing technologies, SMRT sequencing can directly detect DNA base modifications, such as cytosine and adenine methylation or hydroxymethylation, bypassing the need for chemical or enzymatic treatments.


This technology enables the identification of epigenetic modifications throughout the entire genome, yielding a comprehensive view of the epigenetic landscape. By accurately pinpointing DNA modifications, SMRT sequencing can be used to study the epigenetic changes linked with various biological processes like development, aging, and disease.


Researchers can employ SMRT sequencing to inspect epigenetic modifications associated with gene regulation, DNA repair, and other vital cellular processes. Additionally, it can be used to analyze epigenetic changes that occur in response to environmental or physiological stimuli, offering valuable insights into adaptation and disease mechanisms.


While other sequencing technologies, such as bisulfite sequencing or ChIP-seq, have limitations in their capacity to accurately detect all DNA modifications and often necessitate intricate sample preparation protocols, SMRT sequencing is a highly accurate and scalable technology capable of providing an all-encompassing view of the epigenetic landscape in a single experiment. At Deep Biotech Solutions, we use SMRT sequencing to facilitate your research into the expansive field of epigenetics.

SMRT sequencing stands out for its ability to accurately detect and characterize larger insertions, deletions, and copy number variations (CNVs), key structural variants in genomes. Short-read sequencing technologies, with their read sizes of 50bp-300bp, are often prone to errors or misalignments, and they frequently miss or misidentify structural variants, particularly in highly repetitive or complex genomic regions.


In contrast, SMRT sequencing, with its long reads ranging from 1000bp to 100,000bp, exhibits superior performance in identifying structural variants and CNVs. It’s uniquely positioned as the only method capable of accurately detecting larger genomic changes. At Deep Biotech Solutions, we leverage the power of SMRT sequencing to deliver high-quality data for your genomic research, ensuring comprehensive and reliable insights into genomic structural variations.

SMRT sequencing is a powerful tool for de novo genome assembly, enabling researchers to construct new, complete genomes, even from previously unsequenced or complex organisms. Traditional sequencing technologies typically generate short reads (50bp-300bp) which can often result in fragmented or incomplete assemblies. In contrast, SMRT sequencing offers long reads ranging from 1000bp to 100,000bp, providing superior suitability for genome assembly.


These long reads can span large genomic regions, even those that are highly repetitive or complex, thereby leading to fewer gaps and misassemblies and facilitating more complete and accurate genome assemblies. Moreover, SMRT sequencing can resolve structural variations and haplotypes often overlooked by other sequencing technologies, offering a more comprehensive view of the genome and its complexity.


Additionally, SMRT sequencing can deliver high-quality data from a single, long DNA fragment, circumventing the need for laborious library preparation, and hence reducing the risk of introducing biases or errors in the data. This is particularly beneficial for studying organisms with complex genomes, which may require more time and resources for traditional library preparation and sequencing. With Deep Biotech Solutions, leverage the advantages of SMRT sequencing to assemble new, complete genomes, fostering breakthroughs in genomics research.

SMRT sequencing is an invaluable tool in detecting and analyzing both known and novel microbes, offering a comprehensive view of microbial diversity and function within any given environment. A key advantage of SMRT sequencing for metagenomics and microbiome analysis lies in its ability to generate long reads (from 1000bp to 100,000bp). These long reads can span multiple regions of the genome, even those that possess high levels of structural complexity such as repetitive or transposable elements.


This results in fewer gaps in the sequencing data, leading to more accurate and complete genome assemblies. As a result, it paints a more comprehensive picture of the microbial community being studied. Additionally, the long reads produced by SMRT sequencing also facilitate the detection of novel microbes or microbial community members that may go unnoticed by other short-read (from 50bp to 300bp) sequencing technologies. At Deep Biotech Solutions, we employ SMRT sequencing to advance metagenomics and microbiome analysis, helping researchers unlock unprecedented insights into microbial communities.

Frequently Asked Questions

Single Molecule, Real-Time (SMRT) sequencing is a unique method that allows sequencing of individual molecules in real-time. Unlike short-read sequencing technologies, SMRT sequencing provides long-reads, which are particularly useful for resolving complex genomic regions, detecting structural variations, and providing a comprehensive view of the genome.

SMRT Sequencing is adept at detecting structural variations in the genome, including large insertions, deletions, duplications, and rearrangements. These variations often have significant biological implications and can contribute to various diseases.

SMRT Sequencing’s long-reads can span entire repetitive regions or complex genomic structures, allowing us to decipher these challenging areas. This provides a more accurate representation of the genome and helps understand genomic complexities better.

Yes, our SMRT Sequencing service provides a comprehensive epigenetic analysis, including detection of DNA methylation marks on N6-adenine (6mA) and C5-cytosine (5mC). Understanding these epigenetic modifications can provide insights into gene regulation and contribute to our understanding of various diseases.

This service provides you with a detailed, publication-ready materials and methods section, relieving you of the often time-consuming and complex process of preparing this part of a research manuscript. It covers all the methods related to the SMRT sequencing process and subsequent bioinformatics analyses.

We can process and isolate nucleic acids from any sample type, including those considered hard-to-process such as formalin-fixed, paraffin-embedded (FFPE) sections. Our expertise ensures effective handling of all samples, providing high-quality results.

Our 24-hour response time means we will address any questions or issues related to your SMRT sequencing project within a day. This fast response time ensures your project stays on track and facilitates timely adjustments to the analysis or experiment design.

We employ Artificial Intelligence to handle the large and complex data generated by SMRT Sequencing. AI helps identify patterns and make predictions that traditional data analysis methods might miss, yielding deeper and more comprehensive insights.

Your raw and analyzed data will be stored safely on our secure servers for three years with unlimited access. This relieves you of the burden of data management and allows you to revisit and analyze the data whenever necessary, especially useful for long-term research projects and follow-up studies.

es, the long reads provided by SMRT Sequencing are excellent for metagenomics and microbial community analysis, as they allow for a more accurate and detailed identification and characterization of microbial species present in a sample.

Reach out to us if you have any queries about our products. We assure you of a response within 24 hours.

Shopping cart0
There are no products in the cart!